Human Prorenin, Native

Recombinantly produced in HEK cell culture as untagged native form prorenin and purified by affinity chromatography. Fully activatable to renin by catalytic amounts of trypsin. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first 43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site 1. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin but not renin are increased in diabetic subjects2.

1 A.H. Jan Danser, Jaap Deinum , Renin, Prorenin and the Putative Prorenin Receptor. Hypertension. 2005,46:1069.

2 Luetscher JA, Kraemer FB, Wilson DM, Schwartz HC, Bryer-Ash M.Increased plasma inactive renin in diabetes mellitus. A marker of microvascularcomplications. N Engl J Med. 1985,312:1412-1417.



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