In vivo Transfection

BrainFectIN - Finally a real alternative to viral vectors for transfection of neural tissue in small animals

Major drawback with regular gene delivery in the central nervous system that relies on viral methodology is the time needed to prepare the viral vectors and the safety precautions that are necessary. Until now, no real alternative to virus methodology has been available that can offer the same kind of transfection effect of neural tissue in small animals. With BrainFectIN^TM there is finally an alternative available that can match the efficiencies of viral vectors but to a much smaller time investment.

BrainFectIN™ is an original non-viral formulation that allows safe, easy and efficient nucleic acids delivery into central nervous system of small animals. This reagent has been designed by OZ Bioscience R&D team to meet in vivo grade quality (reagents performed under high manufacturing and quality standards and tested by strict quality controls).

• Targeted process (stereotaxic injection)
• Good transfection efficiency
• Reduction of the injection volume
• Reduction of the DNA doses
• Minimized toxicity
• Low immunogenicity
• Rapid and long-term transgene expression

Evaluation Results

Method Insert

Other Solutions

in vivo ViroMag, is an optimized nanoparticles formulation dedicated to viral vectors that allows reduction of titer virus. It is particularly suitable for Lentiviral/Retroviral, Adenoviral and Adeno-Associated Viral (AAV) vectors.

In vivo polyMag, a cationic polymer-based magnetic nanoparticles formulation, designed forin vivo targeted transfection of nucleic acids.

In vivo DogtorMag, a cationic lipid-based magnetic nanoparticles formulation, designed for in vivo targeted transfection of nucleic acids.

In vivo SilenceMag, a cationic lipid-based magnetic nanoparticles formulation, designed to transfect small RNA, into target cell/ tissue in vivo.